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In terms of ventricular load, SGLT2i reduce cardiac load via osmotic diuresis and enhance urinary sodium excretion while also decreasing arterial stiffness and improving endothelial function [109]

GLP-1 drugs target the Area Postrema and dorsal vagal complex , brain regions that control vomiting and food aversion

The need for appropriate registration of pregnancy outcomes under newer oral glucose-lowering therapies

Semaglutide activates GLP-1 receptors throughout the body, triggering weight loss and metabolic changes that occasionally produce muscle cramping in the legs, shoulders, or abdomen

T.Hernandez-BoussardT.RodriguezF

Drug Discovery Today 21, 454464