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Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential

Within this framework, absorption can be considered a metabolic control module: even when dietary composition appears adequate, altered gastrointestinal kinetics may reduce effective delivery of critical substrates, shifting metabolic constraint from nutrient intake to handling efficiency

The dual agonist approach represented by tirzepatide demonstrates that activating multiple complementary pathways produces superior results to targeting a single pathway, even when that single pathway works quite well on its own

Schimmer S

Breit et al., 2018

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