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In the brain, it is distributed in the hypothalamic regions of the arcuate nucleus (ARC), dorsomedial hypothalamus (DMH), ventromedial hypothalamus (VMH), paraventricular hypothalamus (PVH), lateral hypothalamus (LH), and the subfornical organ

Curr Opin Pharmacol (2013) 13(6):9649

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Weight loss typically becomes measurable after four to six weeks of consistent dosing, allowing enough time for the medication to build steady blood levels and for your body to adapt to reduced caloric intake

Similarly, the fetal effects of exenatide, which has a negligible fetal-to-maternal peptide concentration ratio during ex vivo human placental perfusion, are probably due to maternal side effects (34)
