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doi: 10.1186/s12933-016-0371-z

In general, oral diabetes medicines such as metformin are tried first for blood sugar control before injectables such as Ozempic are considered

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Clinical trial data consistently show that these medications produce small to moderate improvements in several lipid parameters, with the magnitude of effect varying by specific agent and patient population

Once the substrate is appropriately positioned, the activated serine nucleophile of the catalytic triad (Ser630) can attack the peptide bond between the second and third residue, and form a tetrahedral covalent intermediate