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Diabetes Ther (2021) 12(8):213347

Scientific reports 7 , 10975, (2017)

Ann Intern Med 1958
Botox or Dysport are given as tiny injections into the muscles of the face, resulting in the dramatic reduction of facial wrinkles and lines
Commercial patches dont disclose dosages but likely contain minimal amounts of active ingredients, far below what clinical studies show is needed for oral berberine (500-1500mg daily)
The conversation also raises bigger questions about transparency in clinical trials, what drug companies knew about these anti-hedonic effects, and why something so impactful may not have been formally tracked
