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Three interrelated factors dominate outcomes: extremely low and variable oral bioavailability, a short systemic elimination half-life, and high-dose sensitivity with narrow therapeutic windows

Cummings DE, Clement K, Purnell JQ, et al

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Both hypothyroidism and hyperthyroidism can alter glucose metabolism, insulin sensitivity and the pharmacodynamics of diabetes mellitus medications

People have reported sicknesses such as gastrointestinal illness, seizures and even hospitalizations

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
