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Research is mixed, but a 2025 systematic review reported that microbiome interventions (e.g., probiotics) generally improved body weight, body fat percentage, and metabolic parameters (e.g., lipid levels, glucose metabolism) in people with obesity

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Are there any drugs approved by the FDA to manage these adverse effects

Its important to note, the science is from PubMed, not the brand

Upon binding to their respective receptors on pancreatic beta cells, GIP and GLP-1 enhance insulin secretion in a glucose-dependent manner

The most common side effects are not mysterious