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Taking advantage of a vast repertoire of these mammalian sensors, cells have been engineered to sense microbe-derived formyl peptides 24 , bile acids 25 , menthol 21 , fatty acids 26 , inflammatory cytokines 27,28 , and to activate therapeutic gene expression in mouse models of liver injury 25 , chronic pain 29 , and psoriasis 27

Previous animal studies reported that GLP-1RA treatment during early pregnancy significantly reduced fetal body weight (27, 34)

Am J Physiol-Endocrinol Metab

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