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It reveals the underlying disease biology again: hunger rises satiety falls energy expenditure stays suppressed the brain becomes more vulnerable to food reward central adiposity starts returning This is why obesity must be discussed like other chronic diseases
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This article covers mechanism, clinical trial evidence, FDA-approved indications, boxed-warning safety, and the FTO, GLP1R, MC4R, and TCF7L2 variants that shape every GLP-1 response
