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The first FDA-approved GLP-1 receptor agonist, exenatide, was introduced for type 2 diabetes in 2005 and required twice-daily injections

Importantly, most side effects occur during dose escalation and tend to improve over time

Tirzepatide with B12 is one of the most common additions

Some patients discontinue treatment due to gastrointestinal discomfort before reaching their weight loss goals

The blog also explains its role in clinical trials

This guide breaks down exactly what Toujeo is, what GLP-1 medications are, why the confusion happens so frequently, and what the differences mean for anyone navigating diabetes treatment or weight loss with peptide-based therapies