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Front Genet
Of all glucose-lowering therapies, only sodiumglucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) consistently result in weight improvement
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GLP-1 agonists offer metabolic and anti-inflammatory benefits, but appetite suppression may drive gut microbiome dysbiosis that offsets long-term outcomes.
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