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Conclusion Glucagon-like peptide-1 receptor agonists (GLP-1RAs) represent a promising therapeutic avenue for heart failure with preserved ejection fraction (HFpEF)

Tirzepatide achieved significant reductions in Glycated Hemoglobin A1c (HbA1c) levels and body weight compared to placebo

Mitochondrial autophagyan essential quality control mechanism for myocardial homeostasis

The change in body weight was evaluated by the researchers, who then used mediation analysis to distinguish between the direct and indirect effects of weight reduction (mediated by GI AEs)