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Unlike semaglutide, Zepbound was available at pharmacies within weeks of approval, though supply constraints persisted for months

Because TRT indications and most outcome data are derived from male endocrine reference ranges, the evidence base included in this review was predominantly limited to adult male populations

Mistake 2: treating the restart like a new beginning instead of a continuation Some people approach their restart with all-or-nothing thinking

SURPASS-2 results (40 weeks, type 2 diabetes): Tirzepatide 5 mg: -7.6 kg weight loss, -2.01% HbA1c reduction Tirzepatide 10 mg: -9.3 kg weight loss, -2.24% HbA1c reduction Tirzepatide 15 mg: -11.2 kg weight loss, -2.30% HbA1c reduction Semaglutide 1 mg: -5.7 kg weight loss, -1.86% HbA1c reduction SURMOUNT-5 results (72 weeks, obesity): Tirzepatide demonstrated statistically superior weight loss compared to semaglutide 2.4 mg