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Simultaneously, reduced food intake means less frequent gallbladder contraction (which normally occurs in response to eating), allowing bile to become more concentrated and stagnant

UK-licensed medications that can increase heart rate include liraglutide (Saxenda) and semaglutide (Wegovy), which typically raise resting heart rate by 24 beats per minute, and naltrexone/bupropion (Mysimba), which can elevate both heart rate and blood pressure

7 GLP-1 agonists are a promising drug class originally developed for the treatment of type 2 diabetes, but recently shown to be effective for weight loss in non-diabetic patients with obesity or overweight BMI when given as adjunctive therapy to diet and exercise

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Off-label use is when a drug is prescribed for a condition other than what it is formally approved for

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