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doi:10.1016/S0009-9236(03)00051-1

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A 2025 review on the effects of weight cycling on muscle and sarcopenia suggested that it may lead to disproportionate fat regain, reduced FFM, accelerated age-related muscle loss and an increased risk for functional impairment and disability, particularly in older or frail individuals, contributing to worsened muscle health outcomes including sarcopenic obesity [14]
[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R