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Patients with higher baseline insulin resistance may experience particularly strong appetite suppression benefits

All of these medications have different dosing schedules and frequencies

Due to the lack of evidence in their effectiveness and their potential to increase unwanted effects it is important that the patient and provider discuss the use in detail

The most useful studies will track MRI findings, relapse activity, disability, biomarkers, body composition, and patient-reported fatigue

Tesamorelin has a more established evidence base, primarily in the context of HIV-associated lipodystrophy, where pivotal randomised controlled trials (including Falutz et al., NEJM, 2010) demonstrated statistically significant reductions in visceral adipose tissue