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Finally, although genetic manipulation is one of the strengths of preclinical work, it is important to recognize that transgenic manipulations can induce developmental compensations in parallel pathways that can mask the overall effect of loss of the gene on surgical outcome

In recent years, the topic of the GLP-1s, drugs such as Ozempic, Wegovy, Mounjaro, Zepound and others has taken the forefront of the discussion of the treatment of overweight and obesity