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GLP-1 plays a role in insulin secretion and blood sugar regulation and also interacts with regions of the brain involved in appetite signaling

doi: 10.1002/0471142735.im2005s45

Although the studies were not powered for stroke outcomes alone, a particularly large benefit was seen with exenatide and dulaglutide use in the EXSCEL and REWIND trials, despite exenatide results not being significant

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Scott Butsch, MD, director of obesity medicine within the Cleveland Clinics Bariatric and Metabolic Institute, postulated that insurers still hesitate to see obesity as a disease and hence to cover treatments for it