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Patients with specific FTO or MC4R variants often benefit from earlier consideration of tirzepatide's dual-receptor approach

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Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles

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In vivo, GLP-1 is a substrate for DPP-4 and is rapidly metabolized to GLP-1 (937) or GLP-1 (936) NH 2 1