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Common side effects include fatigue, nausea, insomnia, dehydration, and digestive problems

Physician-supervised protocols

10.1371/journal.pone.0002119 PLoS One 80 RocaV.CasabonaJ

The combined central and peripheral effects produce a much larger and more durable energy-balance shift than earlier GLP-1 agonists could achieve

, FDA-approved drugs can be broadly classified into 2 major groups based on their nature and mode of action: small molecules and biologics

To prevent muscle loss on GLP-1 medications, prioritize protein at each meal, lift weights at least two to three times per week, and avoid skipping meals entirely
