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Discussion In this phase 3a trial involving adolescents with obesity who were randomly assigned to receive semaglutide or placebo, each with lifestyle intervention, once-weekly subcutaneous semaglutide at a dose of 2.4 mg resulted in clinically relevant decreases in BMI and body weight, with substantially greater proportions of participants in the semaglutide group than in the placebo group reaching the 5 to 20% weight-loss thresholds

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