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10.1007/s11033-012-2290-8 55

Injection site reactions: Watch for any redness, swelling, or itching at the injection site

While the semaglutide CVOTs did not show an increased incidence of hospitalization for HF compared to placebo (101), in earlier smaller studies with liraglutide in patients with HF with reduced left ventricular ejection fraction, the GLP-1RA was associated with increased incidence of serious cardiac events (rhythm disorders, worsening of HF) (102, 103)

and avoiding high-fat or overly sweet foods that may trigger nausea

Nevertheless, these studies appear encouraging and more trials are underway. Although pain reduction remains important in OA, the big question and one representing a massive unmet need is whether the drugs can actually modify OA disease course