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Example: WTW reported that GLP-1 medications now represent 16% of pharmacy spend, up from 1% in 2020, highlighting the importance of modeling three- to five- year budget exposure and management levers

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The landscape of heart failure (HF) management is evolving alongside a deeper understanding of how metabolic dysfunction drives cardiac pathology and the progression of HF, particularly in phenotypes like HF with preserved ejection fraction (HFpEF) associated with obesity

These results provide preliminary real-world evidence that GLP-1RAs may decrease alcohol consumption and subjective alcohol effects in people with obesity [75]