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10.1172/JCI22422 23

Sarrauste de Menthiere C, Chavanieu A, Grassy G, et al

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It became a reasonable option if patients could tolerate an injection with a larger needle (to deliver the suspension)
The blood sugar may not drop dangerously low (true hypoglycemia on tirzepatide monotherapy is rare), but even mild fluctuations can trigger the sympathetic nervous system enough to cause brief awakenings