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N Engl J Med 384(11):9891002 [DOI] [PubMed] [Google Scholar] 19.Davies M, Frch L, Jeppesen OK et al (2021) Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

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Additionally, the I 2 test was employed for further analysis [23]

Persistently elevated concentrations of CRP, TNF-, and IL-6 contribute directly to insulin resistance through serine phosphorylation of IRS-1, impair vascular endothelial function through suppression of endothelial nitric oxide synthase (eNOS) activity, and accelerate the progression of macrovascular disease through promotion of atherogenic lipid modification, foam cell formation, and plaque instability