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History of glucagon-like peptide-1 receptor agonists

60 Two phase 2 clinical trials on firsocostat in monotherapy or in combination with other therapies for NASH regarding safety, efficacy and tolerability, one on patients with stage 2 and 3 fibrosis and another in participants with bridging fibrosis or compensated cirrhosis are expected to finish soon, and results of these studies are awaited (NCT02781584, NCT03449446)

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Discovery of GLP-1 led to elucidation of their conversion to proglucagon by proprotein convertases such as furin [5,6]

GLP-1 receptor agonists routinely produce 1520% weight loss in clinical trials, rivaling results previously seen only with bariatric surgery