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Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)

188,208 Although a modest reduction in lean mass was observed at 12 months, muscle function, assessed via handgrip strength, improved significantly, the prevalence of sarcopenic obesity declined, and resting energy expenditure relative to lean mass increasedindicating enhanced metabolic efficiency

Hsu also points out that these medications prevent the liver from releasing extra sugar into the bloodstream when sugar levels are too high

Keep holding the pen against your skin for approximately 10 seconds after the second click to ensure the full dose is delivered

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Stick to simple, low-fat foods (like the BRAT diet: bananas, rice, applesauce, toast) until it subsides