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In addition, other relevant therapies based on incretins, including GIP receptor (GIP-R) agonists, dual GLP-1R/GIPR agonists, GLP-1R/GIPR/Glucagon receptor (GCGR) triagonists, and oxyntomodulin (OXM), have been shown to improve outcomes of T2DM in a series of preclinical trials ( Table 1 Characteristics of GLP-1 RAs that have been approved to treat type 2 diabetes as of 2021, modified from Li et al

Most symptoms tended to fade over time, Wharton says

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Some patients find that lifestyle modifications, medication adherence improvements, or simple dose optimization unlock results they hadn't achieved previously

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Tirzepatide (marketed as Zepbound) led to average weight losses of up to 18% over 78 weeks