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Studies show that patients with these complications may require 2030% higher doses to achieve the same therapeutic effect as those with healthy injection sites

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Semaglutide produced roughly twice as much weight loss as previously-available drugs (for example orlistat, which doesnt alter appetite but stops the body absorbing fats from food)

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Aging Cell 9 , 304312 (2010)

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But lets zoom out a moment

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[DOI] [PubMed] [Google Scholar] 874.Torgerson JS, Hauptman J, Boldrin MN

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Patients with ESRD have a high burden of comorbidities

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