muscle mass loss glp 1 Do GLP-1 medications really cause major loss? Or have we been misunderstanding what DXA scans are measuring? 🤔 For years, the “40% muscle loss” claim has been one of the biggest Can You Lose Muscle on

Personal dosing (also known as microdosing) GLP-1 medications during menopause involves using sub-clinical doses to manage weight while minimizing side effects

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Curious about your gut's influence on these medications

Others * Long-term metformin use * Proton pump inhibitors (reduce acid absorption) Pathophysiology * Impaired DNA synthesis megaloblastic anemia * Accumulation of methylmalonic acid nerve damage Clinical features Hematological * Fatigue, pallor * Shortness of breath * Megaloblastic anemia Neurological (key distinguishing feature) * Peripheral neuropathy (tingling, numbness) * Loss of vibration and position sense * Ataxia (unsteady gait) * Cognitive changes Severe untreated cases irreversible nerve damage Others * Glossitis (smooth, beefy red tongue) * Mild jaundice Investigations * Serum vitamin B12 * CBC macrocytic anemia ( MCV) * Blood film hypersegmented neutrophils * methylmalonic acid (specific for B12 deficiency) * homocysteine Differentiate from folate deficiency * Both megaloblastic anemia * Only B12 neurological symptoms Management Replacement therapy * Hydroxocobalamin (preferred IM) * Frequent doses initially, then maintenance * Oral B12 if mild and absorption intact Important rule Never give folate alone if B12 deficiency is possible may worsen neurological damage Prevention * Adequate diet (meat, eggs, dairy) * Supplementation in vegans * Monitor high-risk patients (elderly, post-surgery)

Acolo, Tirzepatide este comparat direct cu Semaglutide la pacieni tratai cu metformin i arat o scdere mai mare a HbA1c i o reducere mai pronunat a greutii corporale, ceea ce susine conceptul c activitatea dubl (GIP/GLP-1) poate avea un efect metabolic suplimentar fa de GLP-1 utilizat singur

While these products are often marketed as "wellness" breakthroughs, many have not been assessed for safety, efficacy, or quality, posing severe risks such as hormonal imbalances, liver damage, and infections