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The most commonly reported AE with tirzepatide were gastrointestinal, including nausea, diarrhoea and vomiting

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Important toxicologic components include serotonin, amine oxidase, phospholipase A, substances promoting the release of bradykinin, helodermin, hyaluronidase, and exendin 4

Hemodynamic stresses induce endothelial dysfunction and remodeling of pulmonary artery in experimental compensated heart failurePubMed
