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This reinforces that obesity is a chronic condition requiring long-term management, GLP-1 medications don't "cure" obesity any more than blood pressure medications cure hypertension

When paired with adequate protein intake and resistance-based activity, this process helps preserve lean muscle mass while promoting fat loss, supporting healthier body composition, and metabolic stability

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found similar results regarding HMB supplementation on improving lean body mass with significant increases in fat-free mass in older adults compared to control groups [62]

doi:10.1161/JAHA.125.041369

Exedin-4, a naturally occurring GLP-1RA derived from Gila monster venom, has also been shown to suppress macrophage-driven inflammation by enhancing adiponectin expression