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Key Takeaways Stopping GLP-1 medications can make maintenance harder because hunger increases, fullness signals decrease, and calorie needs drop at a lower weight

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These markers could also be useful to define PD subpopulations that are probable responders to treatment with A2A receptor antagonists and open the way for personalized therapeutic decisions in this field

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This recommendation exists specifically because of semaglutides effect on gastric emptying and the potential for reduced oral contraceptive absorption during those transition periods