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Retrieved 10 April 2023

Yu X, Tang H, Huang L, Yang Y, Tian B, and Yu C

TW is supported by a Mid-Career Fellowship from The Hospital Research Foundation

Yu, S., Wu, X., Ferguson, M., Simmen, R

These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Vomiting (common, affecting up to 1 in 10 people) Constipation (common) Abdominal pain (common) Reduced appetite (very common) These gastrointestinal effects typically occur during dose escalation and often diminish over time as the body adjusts to the medication

This context matters because it suggests GLP-1 therapy may not be uniquely catabolic, but rather an efficient inducer of sustained energy deficit