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Am J Physiol 275: G984-992, 1998

comparative effectiveness and safety of bariatric procedures for weight loss: a PCORnet cohort study

The anti-resorptive effects of the therapy were demonstrated by lower RANK and RANKL levels and increased osteoprotegerin (OPG) levels
The carcinogenic risk of GLP-1RAs remains controversial: large-scale cohort studies have not identified an association with pancreatic cancer 36 , but animal experiments suggest that long-term high-dose use may induce ductal hyperplasia 37,38

Fang, X
Standard guidelines recommend bariatric surgery consultation for BMI 35+ regardless of comorbidities, BMI 30-34.9 with serious obesity-related conditions (Type 2 diabetes, hypertension, sleep apnea, severe joint disease), and specifically for BMI 30-35 with uncontrolled Type 2 diabetes despite medical management
