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In certain clinical trials, when compared to a placebo, patients who used Wegovy lost about 15% of their starting body weight in the first 1 to 1.5 years, Zepbound medication users lost 16%, Foundayo medication users lost 12.4%, and Saxenda users lost 5%
These medicationsincluding semaglutide (injectable Ozempic, oral Rybelsus, injectable Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)mimic the action of endogenous GLP-1 while resisting degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)
While stimulant medication can help you lose weight by curbing hunger, experts warn that it can be addictive in some people (9)

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Circulation 148 , 16061635 (2023)

Users of semaglutide or tirzepatide tend to gain back the most weight, regaining an average of 21.3 lb after stopping the medication
