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This may be of clinical significance especially for medications with a narrow therapeutic index, where small differences in blood concentration might lead to therapeutic failure or adverse reactions

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Emerging data also point to benefits in conditions such as obstructive sleep apnea (OSA) and chronic kidney disease, including tirzepatide for moderate-to-severe OSA in adults with obesity and semaglutide for reducing kidney and cardiovascular risk in adults with CKD and T2D

While state Medicaid programs generally cover all FDA-approved drugs, weight loss medications are an exception, leaving states to decide