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doi:10.1001/JAMAONCOL.2025.2681 Zhao X, Wang M, Wen Z, et al

[9] [3] Clinicians should adhere to these schedules rather than accelerating titration, even when patients are tolerating current doses well

Tsai T, Hsu T, Chen C, Cheng J, Chiou M, Huang C, et al

Medicaid to stop covering weight-loss drugs for obesity in New Hampshire The Alliance for Womens Health and Prevention, in support of coverage for weight-loss drugs, said obesity is associated with over 200 health complications

This observation supports the view that removing a Leucine plug by mechanical force [1,2, 5] is a key step in ligand-induced activation of Drosophila and vertebrate Notch, and further suggests that the Epsin-mediated pulling force is specifically required to accomplish this step

The apparent contradiction between these potential protective mechanisms and clinical observations of retinopathy worsening likely reflects the complex interplay between rapid metabolic changes and pre-existing vascular damage