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They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body

1 2 Diabetes & Metabolism

Medicines.org.uk

In fact, it just increases your risk of side effects
But heres something that your doctor may not have mentioned to you: your skin doesnt always keep up with rapid weight loss

When accompanied by metabolic disorders, such as IR and dyslipidaemia, it can lead to hyperlipidaemia, hypertension, metabolic syndrome and diabetes
