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Not everyone experiences these uncomfortable symptoms, but those who do tend to feel them most severely when they step up to a higher dose of the medicine

Such ratio significantly increased from baseline after 26 weeks of treatment with liraglutide 1.8 mg/day, indicating a reduction in liver steatosis, whereas it was unchanged in patients treated with lower doses of liraglutide, glimepiride or placebo

In many cases, these side effects improve over time, but nutritional monitoring is especially important during the early phases of medication use (Nauck et al., 2021)

NEFA, Non-esterified fatty acids

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Drugs and materials (-)Isoprenaline tartrate was from Sigma Aldrich (Taufkirchen, Germany) and dissolved in water