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For detailed information about TriNetX, please visit their website: Target trial emulation To approximate causal inferences that might arise from a RCT, we applied target trial emulation principles [29]

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There is high relevance of the latter two medication groups to older patients with type 2 diabetes

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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of medications that are effective treatment for patients with type 2 diabetes mellitus (T2DM) and weight control by stimulating insulin secretion, suppressing glucagon secretion, delaying gastric emptying and decreasing appetite. To investigate whether GLP-1RAs might have a positive impact in patients with knee OA, Zhu and colleagues analyzed data from a prospective, observational, multicenter study called the Shanghai Osteoarthritis Cohort