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CBO notes that some analyses of weight loss via GLP-1s found they reduced all-cause mortality in certain patients, while other methods had mixed results notably bariatric surgery, which did not clearly lower future health spending and was heavily dependent on individual adherence to post-surgery lifestyle changes

Patients with T2DM tend to secrete less insulin following a glucose-heavy meal possibly due to decreased levels of glucagon-like peptide-1 (GLP-1) [96]

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Traditionally available only as injections, GLP1 receptor agonists have shown impressive results in lowering blood glucose, aiding in weight loss, and protecting the heart

van Bloemendaal, L., Ten Kulve, J

Comparative studies and head-to-head trials are essential for understanding the distinct attributes of each GLP-1 RA, shedding light on their efficacy, dosing, and side effects to better tailor treatment plans to individual patient needs