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M., Sharpton, T
Phase 2 (Jastreboff 2023) cutaneous category 12.9% at 12 mg vs 1.4% placebo
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GLP-1R agonists (e.g., exendin-4 and liraglutide) reduce APP expression and processing in the brains of AD model mice through the activation of GLP-1R, decrease A protein production and plaque aggregation, and thus improve their spatial memory capacity ( 2.2 GLP-1R and tau protein hyperphosphorylation Hyperphosphorylated tau is a major component of intracellular neurofibrillary tangles (NFTs), which, together with amyloid plaques, are a distinguishing marker of AD (Figure 1)
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10.1038/ncomms6736 17 GuT.JiangA.ZhouC.LinA.ChengQ.LiuZ.et al (2023)
