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Once these patents and marketing exclusivities expire the generic drug can be approved

Zhang Y, Liu Y, Xie Z, Liu Q, Zhuang Y, Xie W, et al

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Another reason for the astronomical amounts is that companies have a relatively short window of time to earn money from their creations
This study was based on electronic medical records from delivery systems in multiple countries and was published in JAMA Network Open

Perkovic, V., et al
