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Glucagon-like peptide-1 receptor agonists

The limitation: During the MOMENTUM trial, participants also exercised more, so isolating the drugs impact is difficult

Because of their intermittent stimulation of the GLP-1R, short-acting GLP-1RAs retain their ability to delay gastric emptying leading to lower postprandial glucose excursions compared with the long-acting GLP-1RAs, which are associated with the development of tolerance (tachyphylaxis) to GLP-1s effect on gastric emptying (10)

The most significant distinction is Mounjaro's dual agonist mechanism

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The overlap between medication side effects and disease symptoms demands a more comprehensive approach