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Additionally, seven lean and six obese subjects underwent a third clamp in which the GLP-1 receptor (GLP-1R) antagonist, exendin (939) amide was infused from -60 to 60 min with GLP-1m from 0 to 60 min

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Semaglutide (Wegovy/Ozempic), which targets only the GLP-1 receptor, has over seven years of real-world data and more than 10 million patients worldwide

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GLP-1 receptors (GLP-1Rs) are found in both the periphery and the central nervous system (CNS), and GLP-1 binding elicits diverse physiological and behavioral effects depending on the site of action (Hayes et al., 2014)

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