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This is because: GLP-1 agonists: Slow gastric emptying, enhance insulin secretion, regulate hepatic glucose Amylin agonists: Suppress appetite centrally, slow gastric emptying via distinct pathways Together: Complementary mechanisms produce additive/synergistic effects on weight loss Cagrilintide Monotherapy Trials Initial clinical development focused on establishing the safety, tolerability, and efficacy of cagrilintide as a standalone therapy for weight management

[DOI] [PubMed] [Google Scholar] 10.Rubino F., Cummings D.E., Eckel R.H., Cohen R.V., Wilding J.P.H., Brown W.A., Stanford F.C., Batterham R.L., Farooqi I.S., Farpour-Lambert N.J., et al