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Zheng H, Li YF, Zucker IH, Patel KP

No significant increase in gastroparesis diagnosis was detected compared to placebo groups in any pivotal trial

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The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice

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As endogenous GLP-1 has a very short half-life, these central actions are likely to be more relevant during therapeutic use of DPP4-resistant GLP-1R analogs, or in post-gastric bypass surgeries, in which GLP-1 equivalent levels, or postprandial GLP-1, respectively, are augmented and sufficient to elicit anorectic responses at these CNS targets