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Akkermansia muciniphila secretes a glucagon-like peptide1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

2021;11(1) doi: 10.1038/s41598-021-96418-0

doi: 10.2337/dc20-2151

[2] The theoretical basis for transdermal berberine delivery rests on principles of percutaneous absorption, but the practical effectiveness depends on numerous factors including patch formulation, skin characteristics, and importantly, berberine's physicochemical properties

Greater efficacy comes at the cost of greater side effect burden for some users

Clinical audiences are equally impressed with the data, hailing a new era for how obesity is perceived and treated, notwithstanding the missed statistical significance for cardiovascular death and the other secondary confirmatory endpoints not being tested for superiority as a consequence
