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The basal GLP-1 secretion in the low-glucose (0.1 mM) state was significantly inhibited by ESI-09, or ESI-09 with H-89, and was stimulated only by 007-AM, a selective EPAC activator (Fig

COR-II Study Group

This may be related to sympathetic activation by DPP4 inhibition (Packer, 2018)

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5 Protein is the highest-priority category because 20-40% of weight loss on GLP-1 medications comes from lean muscle mass, creating genuine clinical demand alongside behavioral preference

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